Photo: Justin Ford / Getty Images Sport / Getty Images
Based on our computer projection model, the Houston Texans will take down the Buffalo Bills when the two teams play at NRG Stadium on Thursday, Nov. 20, which begins at 8:15 p.m. ET. For our predictions on the spead, point total, and final score, check out the rest of the article below.
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Bills vs. Texans Game Info and TV Channel
- When: Thursday, November 20, 2025 at 8:15 p.m. ET
- Where: NRG Stadium in Houston, Texas
- TV: Amazon Prime Video
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Prime Video (Regional restrictions may apply)
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Listen to the game on SportsRadio 610
Bills vs. Texans Odds and Betting Info
- Spread favorite: Bills (-5.5)
- Moneyline: Bills (-275), Texans (+223)
- Total: 44.5 points
Bills vs. Texans Prediction
- Pick ATS: Texans (+5.5)
- Pick OU: Over (44.5)
Prediction:
Texans 26 - Bills 19
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Bills vs. Texans Betting Insights
- The Bills have compiled a 5-5-0 record against the spread this season.
- The Texans have won four games against the spread this year, failing to cover six times.
- Buffalo has covered the spread three times this season (3-4 ATS) when playing as at least 5.5-point favorites.
- The Bills and their opponent have combined to hit the over five out of 10 times this season.
- The Texans and their opponent have combined to hit the over three out of 10 times this season.
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