Cowboys vs. Chargers Week 16 Predictions, Odds and Stats

Which team is going to win on Sunday, Dec. 21, when the Los Angeles Chargers and Dallas Cowboys match up at 1 p.m. ET? Our projection model believes in the Chargers. Dive into our other projections below, where we break down the final score, spread, and over/under.

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Cowboys vs. Chargers Game Info and TV Channel

  • When: Sunday, December 21, 2025 at 1 p.m. ET
  • Where: AT&T Stadium in Arlington, Texas
  • TV: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Listen to the game on 105.3 The Fan

Cowboys vs. Chargers Odds and Betting Info

  • Spread favorite: Cowboys (-1.5)
  • Moneyline: Cowboys (-119), Chargers (+100)
  • Total: 50.5 points

Cowboys vs. Chargers Prediction

  • Pick ATS: Chargers (+1.5)
  • Pick OU: Over (50.5)

Prediction:

Chargers 26 - Cowboys 25

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    Cowboys vs. Chargers Betting Insights

    • The Cowboys are 7-7-0 ATS this season.
    • The Chargers have put together an 8-6-0 ATS record so far this season.
    • Dallas has been favored by 1.5 points or more seven times this season, and covered the spread in two of those games.
    • Los Angeles has an ATS record of 3-0 when playing as at least 1.5-point underdogs this year.
    • So far this season, 10 out of the Cowboys' 14 games have gone over the point total.
    • The Chargers and their opponent have combined to hit the over six out of 14 times this season.

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